Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13008024 | 1.00 | IDO1 (0.55) | IDO1DGAT1TSHRMAPK1AKR1C3 | |
| SCHEMBL434831 | 0.86 | ALDH1A1 (0.48) | IDO1DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL14984446 | 0.86 | ALDH1A1 (0.48) | IDO1DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL10197496 | 0.86 | DGAT1 (0.47) | IDO1DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL382898 | 0.86 | ESR2 (0.56) | DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL15073383 | 0.86 | DGAT1 (0.47) | IDO1DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL15073384 | 0.86 | DGAT1 (0.47) | IDO1DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL15054376 | 0.86 | DGAT1 (0.47) | IDO1DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL17327330 | 0.86 | ESR2 (0.56) | DGAT1ALDH1A1LMNAMAPT | |
| SCHEMBL382897 | 0.86 | ESR2 (0.56) | DGAT1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | IDO1 1972/4885DGAT1 2/4885TSHR 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.