Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16461500 | 0.82 | CES2 (0.42) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 | |
| SCHEMBL1516725 | 0.82 | AKR1C2 (0.64) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 | |
| SCHEMBL30673278 | 0.82 | AKR1C2 (0.64) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 | |
| SCHEMBL30931173 | 0.80 | MEN1 (0.39) | AKR1C2AKR1C1DGAT1KMT2AMEN1 | |
| SCHEMBL4350297 | 0.80 | DGAT1 (0.58) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 | |
| SCHEMBL24992821 | 0.80 | MEN1 (0.39) | AKR1C2AKR1C1DGAT1KMT2AMEN1 | |
| SCHEMBL23087740 | 0.80 | HDAC1 (0.41) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 | |
| SCHEMBL22823904 | 0.79 | HSP90AB1 (0.41) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 | |
| SCHEMBL29365349 | 0.79 | HSP90AB1 (0.41) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 | |
| SCHEMBL1516592 | 0.79 | GAA (0.44) | AKR1C2AKR1C1AKR1C3AKR1C4DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12448392-B2 | Spiropiperidine derivatives | CEPHALON LLC (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250114345-A1 | COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF | ONCOPIA THERAPEUTICS, INC. D/B/A/ SK LIFE SCIENCE LABS | 2025-04-10 | — | — | US | disclosed |
| WO-2025049994-A1 | COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF | ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) | 2025-03-06 | — | — | WO | disclosed |
| US-20240166661-A1 | Spiropiperidine Derivatives | CEPHALON LLC | 2024-05-23 | — | — | US | disclosed |
| US-11878982-B2 | Spiropiperidine derivatives | 89BIO LTD (IL) | 2024-01-23 | — | — | US | disclosed |
| US-20210284651-A1 | Spiropiperidine Derivatives | CEPHALON LLC | 2021-09-16 | — | — | US | disclosed |
| US-11046707-B2 | Spiropiperidine derivatives | 89BIO LTD (IL) | 2021-06-29 | — | — | US | disclosed |
| US-20200031840-A1 | SPIROPIPERIDINE DERIVATIVES | CEPHALON LLC | 2020-01-30 | — | — | US | disclosed |
| EP-3554637-A1 | SPIROPIPERIDINE DERIVATIVES | 89Bio Ltd. (IL) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018112204-A1 | SPIROPIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2018-06-21 | — | — | WO | disclosed |
| EP-2311840-A1 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC S.r.l. (IT) | 2011-04-20 | — | — | EP | disclosed |
| EP-2271634-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, Filial af NeuroSearch Sweden AB, Sverige (DK) | 2011-01-12 | — | — | EP | disclosed |
| US-20100317668-A1 | SUBSTITUTED PYRANO [2,3-B] PYRIDINAMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-7803809-B2 | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20100120774-A1 | Substituted Pyrano [2,3-b] Pyridinamine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-05-13 | — | — | US | disclosed |
| EP-2167471-A1 | SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009133107-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2009-11-05 | — | — | WO | disclosed |
| US-20090275602-A1 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
| US-20090036478-A1 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2009-02-05 | — | — | US | disclosed |
| WO-2008147544-A1 | SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120774-A1 | Substituted Pyrano [2,3-b] Pyridinamine compounds as beta-secretase modulators and methods of use | BACE1, APP, BACE2 | AKR1C2 1164/4885AKR1C1 710/4885AKR1C3 298/4885 |
| US-20090275602-A1 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | BACE1, BACE2, APP | AKR1C2 1226/4885AKR1C1 932/4885AKR1C3 545/4885 |
| US-11878982-B2 | Spiropiperidine derivatives | FASN, FADS2, SCD5 | AKR1C2 49/4885AKR1C1 52/4885AKR1C3 108/4885 |
| US-20100317668-A1 | SUBSTITUTED PYRANO [2,3-B] PYRIDINAMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, APP, BACE2 | AKR1C2 1164/4885AKR1C1 710/4885AKR1C3 298/4885 |
| US-20090036478-A1 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | BACE1, BACE2, APP | AKR1C2 1034/4885AKR1C1 752/4885AKR1C3 518/4885 |
| US-20250114345-A1 | COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF | EP300, CREBBP, HDAC1 | AKR1C2 2647/4885AKR1C1 2684/4885AKR1C3 2153/4885 |
| US-20210284651-A1 | Spiropiperidine Derivatives | FASN, FADS2, SCD5 | AKR1C2 49/4885AKR1C1 52/4885AKR1C3 108/4885 |
| US-20200031840-A1 | SPIROPIPERIDINE DERIVATIVES | FASN, FADS2, SCD5 | AKR1C2 49/4885AKR1C1 52/4885AKR1C3 108/4885 |
| US-12448392-B2 | Spiropiperidine derivatives | FASN, FADS2, SCD5 | AKR1C2 49/4885AKR1C1 52/4885AKR1C3 108/4885 |
| US-20240166661-A1 | Spiropiperidine Derivatives | FASN, FADS2, SCD5 | AKR1C2 49/4885AKR1C1 52/4885AKR1C3 108/4885 |
| US-11046707-B2 | Spiropiperidine derivatives | FASN, FADS2, SCD5 | AKR1C2 49/4885AKR1C1 52/4885AKR1C3 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.