SCHEMBL10198508

SCHEMBL10198508

CC(C)NC1CCC(C(C)C)CC1

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 1/20 0.35
GAA P10253 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ROCK2 O75116 1/20 0.33
ROCK1 Q13464 1/20 0.33
IRAK4 Q9NWZ3 1/20 0.32
GRM4 Q14833 1/20 0.32
CCR2 P41597 1/20 0.30
DRD2 P14416 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12384536 1.00 MDM2 (0.35) MDM2GAAL3MBTL1ROCK2ROCK1
SCHEMBL409484 1.00 MDM2 (0.35) MDM2GAAL3MBTL1ROCK2ROCK1
SCHEMBL18458286 0.86 MDM2 (0.41) MDM2GAAL3MBTL1IRAK4DRD2
SCHEMBL16171239 0.86 MDM2 (0.41) MDM2GAAL3MBTL1IRAK4DRD2
SCHEMBL2600363 0.86 MDM2 (0.41) MDM2GAAL3MBTL1IRAK4DRD2
SCHEMBL681668 0.86
SCHEMBL23366007 0.85 MDM2 (0.41) MDM2
SCHEMBL17827401 0.85 MDM2 (0.41) MDM2
SCHEMBL21501958 0.85 MDM2 (0.41) MDM2
SCHEMBL27089683 0.85 MDM2 (0.41) MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11873288-B2 Inhibitors for soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-01-16 US disclosed
US-11873288-B2 Inhibitors for soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-01-16 US disclosed
US-11672803-B2 Use of inhibitors of Brutons tyrosine kinase (Btk) PHARMACYCLICS LLC (US) 2023-06-13 US disclosed
US-20220249683-A1 T-CELL DEPLETING THERAPIES HEIDELBERG PHARMA RESEARCH GMBH (DE) 2022-08-11 US disclosed
US-20220177575-A1 ANTI-CD117 ANTIBODIES AND USES THEREOF Magenta Therapeutics, Inc. 2022-06-09 US disclosed
US-20220175946-A1 CONDITIONING METHODS FOR GENE THERAPY REGENERON PHARMACEUTICALS, INC. 2022-06-09 US disclosed
US-20220177577-A1 ANTI-CD117 ANTIBODY DRUG CONJUGATES AND USES THEREOF Magenta Therapeutics, Inc. 2022-06-09 US disclosed
US-20220175944-A1 ANTI-CD117 ANTIBODY-DRUG CONJUGATES AND USES THEREOF Magenta Therapeutics, Inc. 2022-06-09 US disclosed
US-20210371524-A1 ANTI-CD45 ANTIBODIES AND CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. 2021-12-02 US disclosed
US-20210155601-A1 INHIBITORS FOR SOLUBLE EPOXIDE HYDROLASE (SEH) AND FATTY ACID AMIDE HYDROLASE (FAAH) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-05-27 US disclosed
US-20150299171-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE CENTAURUS BIOPHARMA CO., LTD. (CN) 2015-10-22 US disclosed
US-9107924-B2 Inhibitors of Bruton'S tyrosine kinase for the treatment of solid tumors PHARMACYCLICS, INC. (US) 2015-08-18 US disclosed
US-8883435-B2 Inhibitors of Bruton's tyrosine kinase PHARMACYCLICS, INC. (US) 2014-11-11 US disclosed
US-20140194446-A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) PHARMACYCLICS, INC. (US) 2014-07-10 US disclosed
US-20140079690-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS PHARMACYCLICS, INC. (US) 2014-03-20 US disclosed
US-20130178483-A1 Methods and Compositions for Inhibition of Bone Resorption PHARMACYCLICS, INC. (US) 2013-07-11 US disclosed
US-20130005745-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC (US) 2013-01-03 US disclosed
US-20120283277-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2012-11-08 US disclosed
US-20120165328-A1 INHIBITORS OF B LYMPHOCYTE KINASE PHARMACYCLICS, INC. (US) 2012-06-28 US disclosed
US-20100254905-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS LLC 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (17 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220177575-A1 ANTI-CD117 ANTIBODIES AND USES THEREOF MYADM, SIGLEC7, ITGB7 MDM2 3538/4885GAA 779/4885L3MBTL1 1997/4885
US-20120165328-A1 INHIBITORS OF B LYMPHOCYTE KINASE BLK, DCK, LTK MDM2 2038/4885GAA 3067/4885L3MBTL1 426/4885
US-20120283277-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, LCK, LYN MDM2 2449/4885GAA 1422/4885L3MBTL1 1139/4885
US-20210371524-A1 ANTI-CD45 ANTIBODIES AND CONJUGATES THEREOF CD44, LY6K, CD2 MDM2 4261/4885GAA 351/4885L3MBTL1 3010/4885
US-11873288-B2 Inhibitors for soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) FAAH, FAAH2, EPHX2 MDM2 3366/4885GAA 2254/4885L3MBTL1 4420/4885
US-20220175944-A1 ANTI-CD117 ANTIBODY-DRUG CONJUGATES AND USES THEREOF ITGB7, KIT, CD2 MDM2 3796/4885GAA 494/4885L3MBTL1 4623/4885
US-20140194446-A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) BTK, SYK, LYN MDM2 3019/4885GAA 2903/4885L3MBTL1 1753/4885
US-20210155601-A1 INHIBITORS FOR SOLUBLE EPOXIDE HYDROLASE (SEH) AND FATTY ACID AMIDE HYDROLASE (FAAH) FAAH, FAAH2, EPHX2 MDM2 3366/4885GAA 2254/4885L3MBTL1 4420/4885
US-20130178483-A1 Methods and Compositions for Inhibition of Bone Resorption BTK, CTTN, BMX MDM2 2635/4885GAA 1661/4885L3MBTL1 2628/4885
US-20220177577-A1 ANTI-CD117 ANTIBODY DRUG CONJUGATES AND USES THEREOF SIGLEC7, FUT7, ITGB7 MDM2 4518/4885GAA 317/4885L3MBTL1 4643/4885
US-20150299171-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, SYK, LYN MDM2 1736/4885GAA 2422/4885L3MBTL1 1900/4885
US-20100254905-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, ABL2 MDM2 2520/4885GAA 1904/4885L3MBTL1 492/4885
US-11672803-B2 Use of inhibitors of Brutons tyrosine kinase (Btk) BTK, LYN, SYK MDM2 2964/4885GAA 3013/4885L3MBTL1 1517/4885
US-20130005745-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, LCK, LYN MDM2 2449/4885GAA 1422/4885L3MBTL1 1139/4885
US-20220175946-A1 CONDITIONING METHODS FOR GENE THERAPY CD74, CD2, CD44 MDM2 4310/4885GAA 210/4885L3MBTL1 1031/4885
US-20140079690-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS BTK, ABL1, LYN MDM2 1656/4885GAA 1771/4885L3MBTL1 345/4885
US-20220249683-A1 T-CELL DEPLETING THERAPIES CD2, CD4, CD22 MDM2 3679/4885GAA 3378/4885L3MBTL1 744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.