Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MRE11 | P49959 | 2/20 | 0.51 |
| ▸ | RRM1 | P23921 | 1/20 | 0.47 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 5/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | USP8 | P40818 | 3/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660600 | 0.86 | MAPT (0.54) | KDM4ERAB9APHGDHADORA3PTGS2 | |
| SCHEMBL2656452 | 0.81 | MEN1 (0.50) | KDM4ERAB9APHGDHMAPK1MEN1 | |
| SCHEMBL2660603 | 0.78 | GCK (0.44) | KDM4ERAB9AMRE11PHGDHMAPK1 | |
| SCHEMBL2657686 | 0.75 | GCK (0.47) | MEN1KMT2AGCK | |
| SCHEMBL10963568 | 0.70 | RAB9A (0.65) | KDM4ERAB9APHGDHPTGS2MAPK1 | |
| SCHEMBL2753592 | 0.70 | MAPT (0.63) | KDM4ERAB9AADORA3MAPK1MEN1 | |
| SCHEMBL1621409 | 0.69 | MAPT (0.56) | RAB9APHGDHADORA3MAPK1MEN1 | |
| SCHEMBL10948598 | 0.69 | MAPT (0.62) | KDM4ERAB9AADORA3MAPK1MEN1 | |
| SCHEMBL10958856 | 0.69 | MAPT (0.62) | KDM4ERAB9AADORA3MAPK1MEN1 | |
| SCHEMBL13323938 | 0.69 | ALDH1A1 (0.43) | KDM4ERAB9AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | disclosed |