Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 9/20 | 0.83 |
| ▸ | IL1B | P01584 | 2/20 | 0.78 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 10/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10199489 | 0.94 | CASP1 (0.89) | CASP1IL1BMMEACELCK | |
| SCHEMBL10199400 | 0.94 | CASP1 (0.81) | CASP1IL1BMMEACELCK | |
| SCHEMBL10199542 | 0.93 | CASP1 (0.80) | CASP1IL1BMMEACELCK | |
| SCHEMBL10199540 | 0.92 | CASP1 (0.79) | CASP1IL1BMMEACELCK | |
| SCHEMBL10199535 | 0.92 | CASP1 (0.79) | CASP1IL1BMMEACELCK | |
| SCHEMBL10199652 | 0.92 | CASP1 (0.79) | CASP1IL1BMMEACELCK | |
| SCHEMBL10201009 | 0.92 | CASP1 (0.83) | CASP1IL1BMMEACELCK | |
| SCHEMBL647901 | 0.92 | CASP1 (0.78) | CASP1IL1BMMEACELCK | |
| SCHEMBL1415723 | 0.92 | CASP1 (0.78) | CASP1IL1BMMEACELCK | |
| SCHEMBL10199785 | 0.91 | CASP1 (0.87) | CASP1IL1BMMEACELCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165319-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165319-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165319-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | IL1A, IFNAR1, IL1B | CASP1 6/4885IL1B 3/4885MME 279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.