Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | CCNC | P24863 | 8/20 | 0.57 |
| ▸ | CDK8 | P49336 | 8/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ATR | Q13535 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019077 | 0.92 | SIGMAR1 (0.69) | SIGMAR1CCNCCDK8EPHX2FLT3 | |
| Trifluoroacetic Acid SCHEMBL27832857 | 0.85 | SIGMAR1 (0.81) | SIGMAR1CCNCCDK8 | |
| Trifluoroacetic Acid SCHEMBL7667828 | 0.81 | POLB (0.80) | POLB | |
| SCHEMBL31054288 | 0.80 | HPGD (0.68) | EPHX2NAMPT | |
| Trifluoroacetic Acid SCHEMBL7669178 | 0.79 | POLB (0.58) | SIGMAR1CCNCCDK8POLBATR | |
| Trifluoroacetic Acid SCHEMBL15565817 | 0.79 | HPGD (0.63) | SIGMAR1EPHX2 | |
| Trifluoroacetic Acid SCHEMBL16150177 | 0.79 | SIGMAR1 (0.59) | SIGMAR1POLB | |
| SCHEMBL1019457 | 0.78 | EPHX2 (0.59) | EPHX2NAMPT | |
| Isophthalic Acid SCHEMBL27637816 | 0.78 | SIGMAR1 (0.68) | SIGMAR1CCNCCDK8 | |
| SCHEMBL1020379 | 0.78 | SIGMAR1 (0.49) | SIGMAR1CCNCCDK8EPHX2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314091-B2 | N-benzyl,N'-arylcarbonylpiperazine derivatives | MSD OSS B.V. (NL) | 2012-11-20 | — | — | US | disclosed |
| EP-2190827-B1 | N-BENZYL-N'-ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | ORGANON NV (NL) | 2011-01-12 | — | — | EP | disclosed |
| EP-2190827-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. Organon (NL) | 2010-06-02 | — | — | EP | disclosed |
| US-20090264416-A1 | N-BENZYL,N'-ARYLCARBONYLPIPERAZINE DERIVATIVES | N.V. ORGANON AND PHARMACOPEIA, INC. | 2009-10-22 | — | — | US | disclosed |
| WO-2009024550-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. ORGANON (NL) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264416-A1 | N-BENZYL,N'-ARYLCARBONYLPIPERAZINE DERIVATIVES | NPC1L1, NPC1, ABCB11 | SIGMAR1 1876/4885CCNC 2517/4885CDK8 4765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.