Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.30 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.30 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
| ▸ | CKS1B | P61024 | 1/20 | 0.30 |
| ▸ | SKP1 | P63208 | 1/20 | 0.30 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018733 | 0.78 | ABL1 (0.51) | ABL1BCRCKS1BSKP1SKP2 | |
| SCHEMBL1018116 | 0.78 | ABL1 (0.39) | ABL1BCRCKS1BSKP1SKP2 | |
| SCHEMBL1021392 | 0.76 | ENPP1 (0.33) | PIM1CDK2FLT4CSNK2A1PRKCD | |
| SCHEMBL4304305 | 0.76 | CKS1B (0.38) | CKS1BSKP1SKP2 | |
| SCHEMBL4304311 | 0.76 | JAK3 (0.36) | — | |
| SCHEMBL1018019 | 0.74 | CNR1 (0.35) | ABL1BCRCKS1BSKP1SKP2 | |
| SCHEMBL27930642 | 0.73 | PIK3CD (0.43) | — | |
| SCHEMBL12082491 | 0.73 | CKS1B (0.49) | CKS1BSKP1SKP2 | |
| SCHEMBL3876920 | 0.72 | KIT (0.45) | CDK2CKS1BSKP1SKP2 | |
| SCHEMBL15654942 | 0.71 | LMNA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |