Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CKS1B | P61024 | 3/20 | 0.34 |
| ▸ | SKP1 | P63208 | 3/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018733 | 0.82 | ABL1 (0.51) | HCRTR2ABL1BCRCKS1BSKP1 | |
| SCHEMBL1018116 | 0.81 | ABL1 (0.39) | CNR2HCRTR2ABL1BCRCKS1B | |
| SCHEMBL4304296 | 0.77 | ROCK2 (0.44) | ROCK2ROCK1CKS1BSKP1SKP2 | |
| SCHEMBL785864 | 0.77 | ITGB3 (0.43) | SLC2A1 | |
| SCHEMBL4304300 | 0.76 | F10 (0.39) | HCRTR2ABL1BCRROCK2ROCK1 | |
| SCHEMBL1018020 | 0.76 | ROCK2 (0.37) | HCRTR2ROCK2ROCK1CKS1BSKP1 | |
| SCHEMBL12082948 | 0.74 | CKS1B (0.54) | ROCK2ROCK1CKS1BSKP1SKP2 | |
| SCHEMBL1021391 | 0.74 | RAF1 (0.32) | ABL1BCRCKS1BSKP1SKP2 | |
| SCHEMBL27809364 | 0.74 | AAK1 (0.44) | HCRTR2ABL1BCRCYP46A1 | |
| SCHEMBL1938711 | 0.70 | TSHR (0.55) | NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |