Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.51 |
| ▸ | BCR | P11274 | 14/20 | 0.51 |
| ▸ | ACACB | O00763 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018116 | 0.86 | ABL1 (0.39) | ABL1BCRHCRTR2CKS1BSKP1 | |
| SCHEMBL1018019 | 0.82 | CNR1 (0.35) | ABL1BCRHCRTR2CKS1BSKP1 | |
| SCHEMBL1021391 | 0.78 | RAF1 (0.32) | ABL1BCRCKS1BSKP1SKP2 | |
| SCHEMBL4304306 | 0.74 | ABL1 (0.48) | ABL1BCRCKS1BSKP1SKP2 | |
| SCHEMBL4304308 | 0.73 | ABL1 (0.52) | ABL1BCRACACBHCRTR2 | |
| SCHEMBL1018735 | 0.72 | ABL1 (0.46) | ABL1BCRHCRTR2 | |
| SCHEMBL13649032 | 0.72 | ABL1 (0.56) | ABL1BCR | |
| SCHEMBL16701397 | 0.72 | ABL1 (0.59) | ABL1BCR | |
| SCHEMBL1939014 | 0.72 | ABL1 (0.53) | ABL1BCR | |
| SCHEMBL12082925 | 0.71 | CKS1B (0.54) | ABL1BCRACACBCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |