Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 16/20 | 0.37 |
| ▸ | HTR3A | P46098 | 10/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2980596 | 1.00 | HTR4 (0.37) | HTR4HTR3ACYP2D6SMN1; SMN2PRMT5 | |
| SCHEMBL1022503 | 1.00 | HTR4 (0.37) | HTR4HTR3ACYP2D6SMN1; SMN2PRMT5 | |
| SCHEMBL1022505 | 1.00 | HTR4 (0.37) | HTR4HTR3ACYP2D6SMN1; SMN2PRMT5 | |
| SCHEMBL3983379 | 0.90 | HRH3 (0.32) | HTR4 | |
| SCHEMBL3986065 | 0.90 | HRH3 (0.32) | HTR4 | |
| SCHEMBL3983380 | 0.88 | KDM4E (0.38) | CYP2D6SMN1; SMN2 | |
| SCHEMBL3986069 | 0.88 | KDM4E (0.38) | CYP2D6SMN1; SMN2 | |
| SCHEMBL3979933 | 0.88 | CYP2D6 (0.32) | CYP2D6SMN1; SMN2 | |
| SCHEMBL2980473 | 0.87 | CYP2D6 (0.31) | CYP2D6SMN1; SMN2 | |
| SCHEMBL2975908 | 0.85 | PIK3CD (0.37) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902053-B1 | BENZOIMIDAZOLONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE INC (US) | 2011-01-12 | — | — | EP | claimed |