Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983380 | 1.00 | KDM4E (0.38) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL2980596 | 0.88 | HTR4 (0.37) | CYP2D6SMN1; SMN2 | |
| SCHEMBL1021565 | 0.88 | HTR4 (0.37) | CYP2D6SMN1; SMN2 | |
| SCHEMBL1022505 | 0.88 | HTR4 (0.37) | CYP2D6SMN1; SMN2 | |
| SCHEMBL1022503 | 0.88 | HTR4 (0.37) | CYP2D6SMN1; SMN2 | |
| SCHEMBL3986065 | 0.87 | HRH3 (0.32) | ALDH1A1LMNAUSP2 | |
| SCHEMBL3983379 | 0.87 | HRH3 (0.32) | ALDH1A1LMNAUSP2 | |
| SCHEMBL2975908 | 0.82 | PIK3CD (0.37) | KDM4EALDH1A1USP2L3MBTL1ALOX15 | |
| SCHEMBL2975909 | 0.82 | PIK3CD (0.37) | KDM4EALDH1A1USP2L3MBTL1ALOX15 | |
| SCHEMBL2965770 | 0.82 | PIK3CD (0.37) | KDM4EALDH1A1USP2L3MBTL1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807423-B1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS | THERAVANCE INC (US) | 2009-05-20 | — | — | EP | disclosed |