Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.43 |
| ▸ | HTR2C | P28335 | 14/20 | 0.43 |
| ▸ | HTR2B | P41595 | 14/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.38 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.38 |
| ▸ | RPS17 | P08708 | 1/20 | 0.38 |
| ▸ | RPSA | P08865 | 1/20 | 0.38 |
| ▸ | RPS2 | P15880 | 1/20 | 0.38 |
| ▸ | RPL35A | P18077 | 1/20 | 0.38 |
| ▸ | RPL7 | P18124 | 1/20 | 0.38 |
| ▸ | RPL17 | P18621 | 1/20 | 0.38 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.38 |
| ▸ | RPS3 | P23396 | 1/20 | 0.38 |
| ▸ | RPS12 | P25398 | 1/20 | 0.38 |
| ▸ | RPL13 | P26373 | 1/20 | 0.38 |
| ▸ | RPL10 | P27635 | 1/20 | 0.38 |
| ▸ | RPL12 | P30050 | 1/20 | 0.38 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 1/20 | 0.38 |
| ▸ | RPL22 | P35268 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10218037 | 0.87 | HTR2C (0.59) | HTR2AHTR2CHTR2BRBP4 | |
| SCHEMBL10218537 | 0.83 | SPR (0.40) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL10218054 | 0.83 | HTR2C (0.58) | HTR2AHTR2CHTR2BRBP4 | |
| SCHEMBL10218564 | 0.83 | HTR2A (0.54) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL14700100 | 0.81 | HTR2A (0.38) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL10218058 | 0.79 | HTR2C (0.57) | HTR2AHTR2CHTR2B | |
| SCHEMBL10218541 | 0.79 | HTR2A (0.37) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL10218531 | 0.78 | HTR2A (0.40) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL13329423 | 0.78 | HTR2A (0.51) | HTR2AHTR2CHTR2BRBP4 | |
| SCHEMBL10218042 | 0.78 | HTR2A (0.55) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346816-B2 | 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-05-24 | — | — | US | disclosed |
| US-9346816-B2 | 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-05-24 | — | — | US | disclosed |
| EP-2384328-B1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM INT (DE) | 2013-02-13 | — | — | EP | disclosed |
| US-20120165304-A1 | 6,7,8,9-Tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| US-20120165304-A1 | 6,7,8,9-Tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| WO-2010060952-A1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165304-A1 | 6,7,8,9-Tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them | HTR1A, HTR2C, TPH1 | HTR2A 9/4885HTR2C 2/4885HTR2B 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.