Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84940 | 0.88 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28752355 | 0.81 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12597955 | 0.81 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14473185 | 0.72 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13790344 | 0.72 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8344453 | 0.71 | PDE4B (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6323001 | 0.70 | PDE4B (0.74) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6322447 | 0.70 | PDE4B (0.74) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6322995 | 0.70 | PDE4B (0.74) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7359174 | 0.70 | PDE4B (0.82) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.