Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18361830 | 0.82 | KDM4E (0.52) | MAPTKDM4EALDH1A1SMN1; SMN2MTNR1A | |
| SCHEMBL13415981 | 0.80 | MTNR1A (0.73) | MAPTKDM4EALDH1A1SMN1; SMN2MTNR1A | |
| SCHEMBL28083588 | 0.76 | CYP2A6 (0.53) | MAPTKDM4EALDH1A1SMN1; SMN2MTNR1A | |
| SCHEMBL30765591 | 0.75 | NAMPT (0.48) | MAPTKDM4EALDH1A1SMN1; SMN2MTNR1A | |
| SCHEMBL28696939 | 0.75 | SIRT1 (0.53) | MAPTKDM4EALDH1A1SMN1; SMN2CYP2A6 | |
| SCHEMBL10173099 | 0.75 | KDM4E (0.42) | MAPTKDM4EALDH1A1SMN1; SMN2MTNR1A | |
| SCHEMBL3578511 | 0.74 | CYP2A6 (0.53) | MAPTKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL6252581 | 0.74 | CYP2A6 (0.58) | MAPTKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL15623133 | 0.74 | CYP2A6 (0.50) | MAPTKDM4EALDH1A1SMN1; SMN2MTNR1A | |
| SCHEMBL28028062 | 0.74 | HPGD (0.52) | MAPTALDH1A1MTNR1AMTNR1BCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083483-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP (NJ) | 2012-04-05 | — | — | US | disclosed |
| WO-2010111483-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083483-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | MAPT 4456/4885KDM4E 3780/4885ALDH1A1 2400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.