Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12795487 | 0.83 | CYP2A6 (0.46) | CYP2A6KEAP1HRH4KDM4EMAPT | |
| SCHEMBL12848262 | 0.83 | CYP2A6 (0.46) | CYP2A6KEAP1HRH4ALDH1A1MMP13 | |
| SCHEMBL4413986 | 0.78 | MTNR1A (0.53) | ALDH1A1KDM4EMAPTMTNR1AMTNR1B | |
| SCHEMBL31487774 | 0.78 | MTNR1A (0.53) | ALDH1A1KDM4EMAPTMTNR1AMTNR1B | |
| SCHEMBL23385240 | 0.78 | CYP2A6 (0.58) | CYP2A6KEAP1HRH4ALDH1A1KDM4E | |
| SCHEMBL15223736 | 0.77 | HDAC2 (0.49) | HRH4MAPTHDAC2KMT2APKM | |
| SCHEMBL12862877 | 0.75 | HRH4 (0.58) | CYP2A6KEAP1HRH4ALDH1A1MMP13 | |
| SCHEMBL10222831 | 0.74 | MAPT (0.52) | CYP2A6KEAP1HRH4ALDH1A1KDM4E | |
| SCHEMBL15450898 | 0.72 | HSD17B10 (0.51) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL5355854 | 0.72 | LMNA (0.63) | ALDH1A1CLK1KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150216844-A1 | SUBSTITUTED CC-1065 ANALOGS AND THEIR CONJUGATES | SYNTARGA B.V. (NL) | 2015-08-06 | — | — | US | disclosed |
| US-8680293-B2 | Substituted CC-1065 analogs and their conjugates | SYNTARGA B.V. (NL) | 2014-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216844-A1 | SUBSTITUTED CC-1065 ANALOGS AND THEIR CONJUGATES | PCNA, TOP1, TOP2B | CYP2A6 2339/4885KEAP1 1871/4885HRH4 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.