Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | AQP1 | P29972 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2741864 | 0.88 | ALDH1A1 (0.69) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL18993639 | 0.87 | KDM4E (0.60) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL2741867 | 0.84 | KDM4E (0.72) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL10222972 | 0.83 | LMNA (0.44) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL2741865 | 0.82 | KDM4E (0.71) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL13283807 | 0.82 | ALDH1A1 (0.61) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL2875002 | 0.82 | KDM4E (0.69) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL2741873 | 0.81 | CA2 (0.68) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL18993714 | 0.80 | KDM4E (0.71) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL15495571 | 0.80 | KDM4E (0.67) | KDM4EUSP2ALDH1A1CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018635-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2010085352-A2 | BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE, AND TORSEMIDE ANALOGS, COMPOSITIONS AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2010-07-29 | — | — | WO | disclosed |