Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10224056 | 0.88 | GGPS1 (0.46) | GGPS1MAPK1TSHRMAOB | |
| SCHEMBL12866793 | 0.86 | GGPS1 (0.50) | GGPS1KDM4EALDH1A1CYP2D6MAPK1 | |
| SCHEMBL12775663 | 0.83 | ALDH1A1 (0.48) | GGPS1KDM4EALDH1A1MAPK1TSHR | |
| SCHEMBL10223981 | 0.83 | GGPS1 (0.42) | GGPS1KDM4EALDH1A1CYP2D6MAPK1 | |
| SCHEMBL18074273 | 0.82 | MEN1 (0.34) | GGPS1KDM4EALDH1A1CYP2D6MAPK1 | |
| SCHEMBL10224029 | 0.81 | CHRNB2 (0.53) | MAPK1TSHRCHRNB2CHRNA4 | |
| SCHEMBL3966708 | 0.81 | KDM4E (0.52) | GGPS1KDM4EALDH1A1GAACYP2D6 | |
| SCHEMBL12775724 | 0.81 | TP53 (0.56) | GGPS1KDM4EALDH1A1CYP2D6MAPK1 | |
| SCHEMBL16841500 | 0.81 | GGPS1 (0.41) | GGPS1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4487459 | 0.81 | KDM4E (0.68) | GGPS1KDM4EALDH1A1GAACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148367-B2 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-04-03 | — | — | US | disclosed |
| US-20100105665-A1 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105665-A1 | RENIN INHIBITORS | REN, ACE, AGT | GGPS1 2094/4885KDM4E 2733/4885ALDH1A1 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.