Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SAT1 | P21673 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL553419 | 0.90 | SAT1 (0.40) | CYP3A4SAT1 | |
| SCHEMBL553373 | 0.85 | CYP3A4 (0.32) | CYP3A4ALDH1A1 | |
| SCHEMBL31480645 | 0.81 | MAOA (0.34) | — | |
| SCHEMBL25169877 | 0.79 | CA12 (0.33) | — | |
| SCHEMBL3815405 | 0.77 | CYP3A4 (0.46) | CYP3A4ALDH1A1 | |
| SCHEMBL3424891 | 0.76 | CYP3A4 (0.34) | CYP3A4ALDH1A1 | |
| SCHEMBL3716029 | 0.76 | CYP3A4 (0.34) | CYP3A4ALDH1A1 | |
| SCHEMBL22772619 | 0.76 | CYP3A4 (0.34) | CYP3A4ALDH1A1 | |
| SCHEMBL20503103 | 0.76 | ALDH1A1 (0.61) | CYP3A4ALDH1A1 | |
| SCHEMBL3429790 | 0.76 | CYP3A4 (0.34) | CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601177-B1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2017-10-18 | — | — | EP | disclosed |
| US-20160176906-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2016-06-23 | — | — | US | disclosed |
| US-9248140-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2016-02-02 | — | — | US | disclosed |
| US-20150328239-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2015-11-19 | — | — | US | disclosed |
| US-9018381-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2015-04-28 | — | — | US | disclosed |
| US-20130310344-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (UK) | 2013-11-21 | — | — | US | disclosed |
| US-20120035134-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | US | disclosed |
| WO-2012017251-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035134-A1 | CHEMICAL COMPOUNDS | BCL2, BCL2L1, BAX | CYP3A4 1309/4885SAT1 4768/4885ALDH1A1 1025/4885 |
| US-20150328239-A1 | Chemical Compounds | BCL2, BCL2L1, BAX | CYP3A4 1309/4885SAT1 4768/4885ALDH1A1 1025/4885 |
| US-20160176906-A1 | Chemical Compounds | BCL2, BCL2L1, BAX | CYP3A4 1309/4885SAT1 4768/4885ALDH1A1 1025/4885 |
| US-20130310344-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | BCL2, BAX, BCLAF1 | CYP3A4 3076/4885SAT1 1834/4885ALDH1A1 2563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.