Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27780337 | 0.87 | KEAP1 (0.49) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL29566 | 0.85 | KEAP1 (0.47) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL2334381 | 0.85 | ALDH1A1 (0.57) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL16632529 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL8482266 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL8482265 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL1548854 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL16041940 | 0.82 | KEAP1 (0.54) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| SCHEMBL5500307 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 | |
| Ethane SCHEMBL7194508 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2TSHRCASP1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110302733-B | Preparation method of double-halogen nitrogen-containing heterocyclic compound | 北京六合宁远科技有限公司 | 2021-07-30 | — | — | CN | claimed |
| CN-110302733-B | Preparation method of double-halogen nitrogen-containing heterocyclic compound | 北京六合宁远科技有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-110302733-B | Preparation method of double-halogen nitrogen-containing heterocyclic compound | 北京六合宁远科技有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-110302733-A | Preparation method of double-halogen nitrogen-containing heterocyclic compound | 北京六合宁远科技有限公司 | 2019-10-08 | — | — | CN | disclosed |
| US-8461107-B2 | HCV NS3 protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110224208-A1 | NOVEL INHIBITORS OF FLAVIVIRUS REPLICATION | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2011-09-15 | — | — | US | disclosed |
| EP-2358682-A2 | ISOQUINOLONE DERIVATIVES AS INHIBITORS OF PLAVIVIRUS REPLICATION | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2011-08-24 | — | — | EP | disclosed |
| CN-102014911-A | HCV NS3 protease inhibitors | MERCK & CO INC | 2011-04-13 | — | — | CN | disclosed |
| US-20110046161-A1 | HCV NS3 PROTEASE INHIBITORS | MERCK SHARP & DOHME LLC | 2011-02-24 | — | — | US | disclosed |
| EP-2271345-A1 | HCV NS3 PROTEASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2011-01-12 | — | — | EP | disclosed |
| US-4801593-A | VIRICIDE FOR RHINITIS VIRUS CONTAINING 2-PHENYLTETRALIN DERIVATIVE | BURROUGHS WELLCOME CO. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0299663-A2 | Antihistaminic aromatic tetrahydroazepinones (and thiones) | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1989-01-18 | — | — | EP | disclosed |
| US-4746657-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-05-24 | — | — | US | disclosed |
| EP-0025598-B1 | THE USE OF 2-PHENYLTETRALIN DERIVATIVES, OR HETEROCYCLIC ANALOGUES, IN MEDICINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-08-01 | — | — | EP | disclosed |
| US-4335129-A | ANALGESIC, ANTIINFLAMMATORY | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1982-06-15 | — | — | US | disclosed |
| US-4329455-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1982-05-11 | — | — | US | disclosed |
| EP-0025598-A1 | The use of 2-phenyltetralin derivatives, or heterocyclic analogues, in medicine and pharmaceutical compositions containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-03-25 | — | — | EP | disclosed |
| US-4163844-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1979-08-07 | — | — | US | disclosed |
| US-4025505-A | ANTICONVULSANTS | CIBA-GEIGY CORPORATION (US) | 1977-05-24 | — | — | US | disclosed |
| US-3998954-A | 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflammatory agents | PFIZER INC. (US) | 1976-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046161-A1 | HCV NS3 PROTEASE INHIBITORS | HAVCR2, GTF3C3, CTSC | SMN1; SMN2 4284/4885TSHR 4610/4885CASP1 179/4885 |
| US-20110224208-A1 | NOVEL INHIBITORS OF FLAVIVIRUS REPLICATION | MAVS, IRF3, EIF2AK2 | SMN1; SMN2 4405/4885TSHR 4780/4885CASP1 1649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.