Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR2 | Q9HBW0 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214852 | 0.86 | LPAR2 (0.42) | LPAR2CD38 | |
| SCHEMBL2477392 | 0.85 | MAPK1 (0.41) | LPAR2GPR119CD38 | |
| SCHEMBL15214864 | 0.85 | LPAR2 (0.40) | LPAR2PDE4BPDE7AGPR119CD38 | |
| SCHEMBL10176269 | 0.82 | LPAR2 (0.39) | LPAR2PDE4BPDE7AGPR119SYK | |
| SCHEMBL27410321 | 0.72 | LPAR2 (0.51) | LPAR2LPAR1 | |
| SCHEMBL30808044 | 0.69 | PDPK1 (0.48) | LPAR2 | |
| SCHEMBL16864137 | 0.65 | SMN1; SMN2 (0.37) | GPR119POLB | |
| SCHEMBL14478872 | 0.63 | FGFR1 (0.60) | — | |
| SCHEMBL24671042 | 0.62 | CYP2C19 (0.36) | SYK | |
| SCHEMBL30715861 | 0.62 | PDE4B (0.51) | LPAR2PDE4BPDE7ASYKCD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |