Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRE | P78334 | 2/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101719 | 0.79 | POLQ (0.48) | POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23723541 | 0.78 | ALDH1A1 (0.44) | GPBAR1POLBGABRPGABRDGABRA1 | |
| SCHEMBL11326229 | 0.78 | GPBAR1 (0.43) | GPBAR1POLBGABRPGABRDGABRA1 | |
| SCHEMBL30120720 | 0.78 | ALDH1A1 (0.44) | GPBAR1POLBGABRPGABRDGABRA1 | |
| SCHEMBL616400 | 0.78 | KMT2A (0.55) | MAOAMAOBHTT | |
| SCHEMBL30120639 | 0.77 | GPBAR1 (0.43) | GPBAR1POLBGABRPGABRDGABRA1 | |
| SCHEMBL7502941 | 0.77 | GABRP (0.55) | GPBAR1POLBGABRPGABRDGABRA1 | |
| SCHEMBL23723502 | 0.77 | GPBAR1 (0.43) | GPBAR1POLBGABRPGABRDGABRA1 | |
| SCHEMBL102917 | 0.76 | FFAR1 (0.38) | GPBAR1MAPTPIK3CA | |
| SCHEMBL1818248 | 0.76 | ALOX5 (0.55) | MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426115-A2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | Addex Pharma SA (CH) | 2012-03-07 | — | — | EP | disclosed |
| US-8101637-B2 | Alkynyl derivatives as modulators of metatropic glutamate receptors | ADDEX PHARMA SA (CH) | 2012-01-24 | — | — | US | disclosed |