Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709528 | 0.87 | ABL1 (0.46) | LMNAMAPK8MAPK9SMN1; SMN2NPC1 | |
| SCHEMBL1682895 | 0.70 | ABL1 (0.51) | LMNATSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1709529 | 0.69 | ABL1 (0.47) | LMNATSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13562821 | 0.65 | NPC1 (0.60) | LMNATSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10237738 | 0.65 | ABL1 (0.45) | TSHRSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL11790355 | 0.64 | ALDH1A1 (0.44) | TSHRALDH1A1GAAHPGDL3MBTL1 | |
| SCHEMBL6831704 | 0.63 | ALDH1A1 (0.75) | ALDH1A1GAAL3MBTL1 | |
| SCHEMBL10937620 | 0.63 | SMN1; SMN2 (0.68) | LMNATSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL15977059 | 0.62 | PLA2G2A (0.57) | TSHRSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL17414620 | 0.62 | PLA2G2A (0.62) | TSHRSMN1; SMN2NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045124-A1 | BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS | BIOTA EUROPE LTD (GB) | 2012-04-12 | — | — | WO | disclosed |