Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.68 |
| ▸ | NPC1 | O15118 | 8/20 | 0.68 |
| ▸ | RAB9A | P51151 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.59 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.59 |
| ▸ | SCD | O00767 | 1/20 | 0.59 |
| ▸ | CASP2 | P42575 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10576093 | 0.91 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL7786534 | 0.85 | CASP2 (0.77) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL10935498 | 0.81 | NPC1 (0.75) | SMN1; SMN2NPC1RAB9ALMNAHSD17B10 | |
| Tioxidazole SCHEMBL1033860 | 0.81 | LMNA (1.00) | SMN1; SMN2NPC1RAB9ALMNAHSD17B10 | |
| Tioxidazole SCHEMBL23382 | 0.81 | LMNA (1.00) | SMN1; SMN2NPC1RAB9ALMNAHSD17B10 | |
| SCHEMBL6229213 | 0.81 | SMN1; SMN2 (0.82) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| Tioxidazole SCHEMBL3053813 | 0.80 | LMNA (0.98) | SMN1; SMN2NPC1RAB9ALMNAHSD17B10 | |
| SCHEMBL15376318 | 0.79 | MAPT (0.78) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| Tioxidazole SCHEMBL21192520 | 0.79 | LMNA (0.95) | SMN1; SMN2NPC1RAB9ALMNAHSD17B10 | |
| SCHEMBL10936133 | 0.79 | DYRK1A (0.74) | SMN1; SMN2NPC1RAB9ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0051560-B1 | MONOAZOPIGMENTS CONTAINING HETEROCYCLIC NUCLEI, THEIR PREPARATION AND USE | CIBA-GEIGY AG (CH) | 1985-01-16 | — | — | EP | disclosed |
| US-4400319-A | Monoazo pigments containing heterocycles, and high-molecular organic materials dyed therewith | CIBA-GEIGY CORPORATION (US) | 1983-08-23 | — | — | US | disclosed |
| EP-0051560-A1 | Monoazopigments containing heterocyclic nuclei, their preparation and use | CIBA-GEIGY AG (CH) | 1982-05-12 | — | — | EP | disclosed |