Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.82 |
| ▸ | DRD2 | P14416 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.72 |
| ▸ | TSHR | P16473 | 6/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13641084 | 0.98 | HTT (0.80) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL13164948 | 0.95 | HTT (0.75) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL7661912 | 0.89 | DRD2 (1.00) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL13641058 | 0.84 | HTT (0.67) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL5255486 | 0.83 | ALDH1A1 (0.63) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL16406276 | 0.83 | ALDH1A1 (0.68) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL18313846 | 0.82 | HTT (0.65) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL13640907 | 0.81 | HTT (0.63) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL16211012 | 0.81 | ALDH1A1 (1.00) | HTTDRD2ALDH1A1TSHRMAPK1 | |
| SCHEMBL13641147 | 0.81 | STAT3 (0.71) | HTTDRD2ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981981-B2 | Tricyclic proteasome activity enhancing compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-29 | — | — | US | disclosed |
| EP-2595993-B1 | TRICYCLIC PROTEASOME ACTIVITY ENHANCING COMPOUNDS | HARVARD COLLEGE (US) | 2018-04-18 | — | — | EP | disclosed |
| US-20160039839-A1 | Tricyclic Proteasome Activity Enhancing Compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-02-11 | — | — | US | disclosed |
| US-8933087-B2 | Tricyclic proteasome activity enhancing compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-01-13 | — | — | US | disclosed |
| US-20130210845-A1 | Tricyclic Proteasome Activity Enhancing Compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-08-15 | — | — | US | disclosed |
| WO-2012012712-A2 | TRICYCLIC PROTEASOME ACTIVITY ENHANCING COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210845-A1 | Tricyclic Proteasome Activity Enhancing Compounds | PSME3, PSME1, PSMG3 | HTT 199/4885DRD2 4507/4885ALDH1A1 4001/4885 |
| US-20160039839-A1 | Tricyclic Proteasome Activity Enhancing Compounds | PSME3, PSME1, PSMG3 | HTT 199/4885DRD2 4507/4885ALDH1A1 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.