Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 19/20 | 0.70 |
| ▸ | MMP9 | P14780 | 19/20 | 0.70 |
| ▸ | MMP14 | P50281 | 15/20 | 0.70 |
| ▸ | MMP8 | P22894 | 9/20 | 0.70 |
| ▸ | MMP7 | P09237 | 7/20 | 0.70 |
| ▸ | MMP3 | P08254 | 6/20 | 0.70 |
| ▸ | MMP1 | P03956 | 2/20 | 0.70 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.70 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238448 | 0.96 | MMP2 (0.78) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL2684163 | 0.82 | MMP2 (1.00) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL10187472 | 0.81 | MMP2 (0.66) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL10239044 | 0.80 | MMP2 (0.73) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL10239036 | 0.79 | MMP9 (0.71) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL10238440 | 0.76 | MMP2 (0.80) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL10238452 | 0.75 | MMP2 (1.00) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL12747549 | 0.75 | MMP2 (1.00) | MMP2MMP9MMP14MMP8MMP7 | |
| SCHEMBL7108878 | 0.75 | CA12 (0.74) | MMP2MMP9MMP14MMP1ADAM17 | |
| SCHEMBL10238435 | 0.74 | MMP2 (0.57) | MMP2MMP9MMP14MMP8MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093287-B2 | Inhibitors of matrix metalloproteinases | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2012-01-10 | — | — | US | disclosed |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | NOTRE DAME UNIVERSITY (US) | 2011-09-15 | — | — | US | disclosed |
| US-7928127-B2 | Inhibitors of matrix metallaproteinases | NOTRE DAME UNIVERSITY (US) | 2011-04-19 | — | — | US | disclosed |
| US-20090005420-A1 | Inhibitors of Matrix Metallaproteinases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005420-A1 | Inhibitors of Matrix Metallaproteinases | MMP9, MMP1, MMP2 | MMP2 3/4885MMP9 1/4885MMP14 15/4885 |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | MMP9, MMP1, MMP2 | MMP2 3/4885MMP9 1/4885MMP14 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.