SCHEMBL10239576

SCHEMBL10239576

FC(F)(F)c1ccc(-n2nnnc2CCN2C=COCC2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.37
CYP2C19 P33261 1/20 0.37
ALDH1A1 P00352 5/20 0.36
LMNA P02545 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
THRB P10828 1/20 0.36
CA12 O43570 1/20 0.34
CA9 Q16790 1/20 0.34
NPSR1 Q6W5P4 2/20 0.33
MAPT P10636 2/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NOTUM Q6P988 1/20 0.33
PRMT1 Q99873 2/20 0.33
DRD3 P35462 2/20 0.32
RAB9A P51151 1/20 0.32
CTDSP1 Q9GZU7 1/20 0.32
HSD11B1 P28845 2/20 0.31
MMP2 P08253 1/20 0.31
MMP3 P08254 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL327688 0.79 CYP1A2 (0.54) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
Hydrochloric Acid SCHEMBL324412 0.78 CYP1A2 (0.53) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL15167746 0.72 SIGMAR1 (0.42) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL15169648 0.72 LMNA (0.36) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL15167749 0.72 SIGMAR1 (0.42) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL324009 0.72 CYP1A2 (0.70) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL25245135 0.70 LMNA (0.44) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL324352 0.70 ALDH1A1 (0.64) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL15179403 0.70 ALDH1A1 (0.56) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL15168454 0.70 ALDH1A1 (0.60) CYP1A2CYP2C19ALDH1A1LMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012004604-A1 TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS Convergence Pharmaceuticals Limited (GB) 2012-01-12 WO disclosed