Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.42 |
| ▸ | ADCY5 | O95622 | 5/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10233932 | 0.88 | CA2 (0.46) | CTSL | |
| SCHEMBL192286 | 0.84 | NAE1 (0.54) | CTSLADORA3ADORA2AADORA1 | |
| SCHEMBL12567124 | 0.82 | ABL1 (0.49) | CTSLADORA3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13192031 | 0.79 | NAE1 (0.44) | CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL10293821 | 0.79 | NAE1 (0.51) | CTSLNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2740595 | 0.78 | METTL3 (0.49) | ADORA3ADORA2AADORA1CCNA2CDK2 | |
| SCHEMBL1794568 | 0.78 | SLC29A1 (0.64) | ADORA3ADORA2AADORA1SLC29A1 | |
| SCHEMBL10293817 | 0.77 | NAE1 (0.44) | — | |
| SCHEMBL2740570 | 0.76 | NAE1 (0.44) | ADORA3SMN1; SMN2 | |
| SCHEMBL13191975 | 0.76 | NAE1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-A1 | Inhibitors of E1 Activating Enzymes | Millennium Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |