Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.49 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.49 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.45 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.45 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10233932 | 0.90 | CA2 (0.46) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL10293821 | 0.90 | NAE1 (0.51) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL13192031 | 0.89 | NAE1 (0.44) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL2740570 | 0.87 | NAE1 (0.44) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL191182 | 0.85 | NAE1 (0.61) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL10236878 | 0.85 | NAE1 (0.43) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL10293824 | 0.85 | NAE1 (0.48) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL14447556 | 0.85 | NAE1 (0.45) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL10242205 | 0.84 | NAE1 (0.49) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL2740568 | 0.84 | NAE1 (0.47) | NAE1CA2GRK5CSNK1A1UBA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989206-B1 | INHIBITORS OF E1 ACTIVATING ENZYME | MILLENNIUM PHARM INC (US) | 2012-07-04 | — | — | EP | disclosed |
| EP-2402334-A1 | Inhibitors of E1 Activating Enzymes | Millennium Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |