Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 19/20 | 1.00 |
| ▸ | STAT1 | P42224 | 2/20 | 0.81 |
| ▸ | STAT5B | P51692 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29374125 | 1.00 | STAT3 (1.00) | STAT3STAT1STAT5B | |
| SCHEMBL16130770 | 0.96 | STAT3 (0.92) | STAT3STAT1STAT5B | |
| SCHEMBL16767563 | 0.93 | STAT3 (0.88) | STAT3STAT1STAT5B | |
| SCHEMBL16766987 | 0.93 | STAT3 (1.00) | STAT3STAT1STAT5B | |
| SCHEMBL10243282 | 0.89 | STAT3 (0.86) | STAT3STAT1STAT5B | |
| SCHEMBL18854629 | 0.89 | STAT3 (0.92) | STAT3STAT1STAT5B | |
| SCHEMBL29615046 | 0.89 | STAT3 (1.00) | STAT3STAT1STAT5B | |
| SCHEMBL10244579 | 0.89 | STAT3 (1.00) | STAT3 | |
| SCHEMBL10243528 | 0.89 | STAT3 (1.00) | STAT3STAT1STAT5B | |
| SCHEMBL10244659 | 0.89 | STAT3 (1.00) | STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297623-B1 | TREATMENT OF MALIGNANT PERIPHERAL NERVE SHEATH TUMORS BY TARGETING APE1/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES | UNIV INDIANA RES & TECH CORP (US) | 2020-10-28 | — | — | EP | claimed |
| WO-2018232238-A1 | THERAPEUTIC AGENT FOR TUBEROUS SCLEROSIS COMPLEX (TSC) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2018-12-20 | — | — | WO | claimed |
| US-20180200213-A1 | METHODS OF TARGETING APE/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-07-19 | — | — | US | claimed |
| EP-3297623-A1 | METHODS OF TARGETING APE1/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES | Indiana University Research & Technology Corporation (US) | 2018-03-28 | — | — | EP | claimed |
| WO-2016186853-A1 | METHODS OF TARGETING APE1/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-11-24 | — | — | WO | claimed |
| US-11786457-B2 | Peritumoral and intratumoral materials for cancer therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-10-17 | — | — | US | disclosed |
| US-11786457-B2 | Peritumoral and intratumoral materials for cancer therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-10-17 | — | — | US | disclosed |
| US-11746120-B2 | Stat degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-20210069230-A1 | SYNERGISTIC DRUG COMBINATIONS PREDICTED FROM GENOMIC FEATURES AND SINGLE-AGENT RESPONSE PROFILES | THE BROAD INSTITUTE, INC. (US) | 2021-03-11 | — | — | US | disclosed |
| EP-3297623-B1 | TREATMENT OF MALIGNANT PERIPHERAL NERVE SHEATH TUMORS BY TARGETING APE1/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES | UNIV INDIANA RES & TECH CORP (US) | 2020-10-28 | — | — | EP | disclosed |
| WO-2020206424-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | YALE UNIVERSITY | 2020-08-27 | — | — | US | disclosed |
| US-20150038708-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-05 | — | — | US | disclosed |
| US-20150038708-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-05 | — | — | US | disclosed |
| US-8846707-B2 | Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of stat protein | UNIVERISTY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846707-B2 | Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of stat protein | UNIVERISTY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846707-B2 | Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of stat protein | UNIVERISTY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130225621-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | UNIVERSITY OF TORONTO MISSISSAUGA (CA) | 2013-08-29 | — | — | US | disclosed |
| US-20130225621-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | UNIVERSITY OF TORONTO MISSISSAUGA (CA) | 2013-08-29 | — | — | US | disclosed |
| WO-2012018868-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11786457-B2 | Peritumoral and intratumoral materials for cancer therapy | CD47, CD68, GZMB | STAT3 249/4885STAT1 626/4885STAT5B 964/4885 |
| US-20150038708-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | STAT3, STAT1, STAT4 | STAT3 1/4885STAT1 2/4885STAT5B 5/4885 |
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | PPP5C, PPP4C, DUSP26 | STAT3 806/4885STAT1 449/4885STAT5B 1389/4885 |
| US-11746120-B2 | Stat degraders and uses thereof | STAT4, STAT1, STAT3 | STAT3 3/4885STAT1 2/4885STAT5B 9/4885 |
| US-20130225621-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | STAT3, STAT1, STAT4 | STAT3 1/4885STAT1 2/4885STAT5B 5/4885 |
| US-20180200213-A1 | METHODS OF TARGETING APE/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES | HIF1AN, APEX1, HIF1A | STAT3 454/4885STAT1 369/4885STAT5B 1775/4885 |
| US-20210069230-A1 | SYNERGISTIC DRUG COMBINATIONS PREDICTED FROM GENOMIC FEATURES AND SINGLE-AGENT RESPONSE PROFILES | ABCC1, TSG101, BRCA1 | STAT3 814/4885STAT1 297/4885STAT5B 1116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.