Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.63 |
| ▸ | DRD3 | P35462 | 3/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | DRD4 | P21917 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | EBP | Q15125 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11646224 | 0.90 | SIGMAR1 (0.55) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| SCHEMBL11650019 | 0.85 | SIGMAR1 (0.46) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| SCHEMBL13271382 | 0.82 | CYP2D6 (0.44) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| SCHEMBL9325508 | 0.81 | OPRM1 (0.56) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| Hydrochloric Acid SCHEMBL10926134 | 0.81 | OPRM1 (0.56) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| SCHEMBL11530730 | 0.81 | CYP2D6 (0.56) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| Hydrochloric Acid SCHEMBL9571830 | 0.80 | OPRM1 (0.55) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| SCHEMBL10925326 | 0.80 | TAAR1 (0.53) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| SCHEMBL11646369 | 0.80 | SIGMAR1 (0.64) | OPRM1DRD3DRD2CYP2D6DRD4 | |
| SCHEMBL11630708 | 0.79 | CCR1 (0.45) | OPRM1DRD3DRD2CYP2D6DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093400-B2 | Compounds useful in therapy | PFIZER INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100317652-A1 | Compounds Useful In Therapy | PFIZER INC | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317652-A1 | Compounds Useful In Therapy | AVPR1A, AVPR1B, AVPR2 | OPRM1 60/4885DRD3 715/4885DRD2 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.