Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA7 | P43166 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6885396 | 0.74 | MAPT (0.38) | ALDH1A1SMN1; SMN2CYP1A2TSHRHPGD | |
| SCHEMBL11210171 | 0.71 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPK1CYP1A2TSHR | |
| SCHEMBL24612064 | 0.68 | CA12 (0.39) | ALDH1A1SMN1; SMN2MAPK1CYP1A2TSHR | |
| SCHEMBL7019135 | 0.66 | MAPT (0.39) | ALDH1A1SMN1; SMN2CYP1A2TSHRKDM4E | |
| SCHEMBL15614506 | 0.65 | KDM4E (0.40) | ALDH1A1SMN1; SMN2POLBMAPK1CYP1A2 | |
| SCHEMBL15614483 | 0.65 | KDM4E (0.44) | ALDH1A1SMN1; SMN2POLBMAPK1TSHR | |
| SCHEMBL5512129 | 0.65 | KDM4E (0.44) | ALDH1A1SMN1; SMN2POLBMAPK1TSHR | |
| SCHEMBL688952 | 0.64 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2POLBMAPK1HPGD | |
| SCHEMBL10756252 | 0.63 | CYP1A2 (0.43) | ALDH1A1SMN1; SMN2POLBMAPK1CYP1A2 | |
| SCHEMBL6623726 | 0.63 | CYP1A2 (0.43) | ALDH1A1SMN1; SMN2CYP1A2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022254-A1 | SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022254-A1 | SIRTUIN MODULATING COMPOUNDS | SIRT1, SIRT3, SIRT2 | ALDH1A1 1825/4885SMN1; SMN2 1572/4885POLB 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.