Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17350520 | 1.00 | HSD11B1 (0.54) | HSD11B1GAANPSR1DRD3HCRTR2 | |
| SCHEMBL10243751 | 0.90 | KMT2A (0.52) | HSD11B1GAANPSR1HCRTR2MGLL | |
| SCHEMBL17350865 | 0.90 | KMT2A (0.52) | HSD11B1GAANPSR1HCRTR2MGLL | |
| SCHEMBL10243919 | 0.83 | PKM (0.48) | GAAALDH1A1L3MBTL1KMT2AHTT | |
| SCHEMBL17350675 | 0.83 | PKM (0.48) | GAAALDH1A1L3MBTL1KMT2AHTT | |
| SCHEMBL17350994 | 0.81 | HSD11B1 (0.55) | HSD11B1GAAHCRTR2ALDH1A1HTT | |
| SCHEMBL10243773 | 0.81 | HSD11B1 (0.55) | HSD11B1GAAHCRTR2ALDH1A1HTT | |
| SCHEMBL10244093 | 0.81 | SLC18A3 (0.49) | HCRTR2HTR2AALDH1A1KMT2APOLB | |
| SCHEMBL17350818 | 0.81 | SLC18A3 (0.49) | HCRTR2HTR2AALDH1A1KMT2APOLB | |
| SCHEMBL17350960 | 0.80 | HSD11B1 (0.50) | HSD11B1MGLLHTR2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | HSD11B1, HSD11B2, HSD17B1 | HSD11B1 1/4885GAA 296/4885NPSR1 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.