Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 2/20 | 0.52 |
| ▸ | WNT3A | P56704 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CCNC | P24863 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2682867 | 1.00 | CTNNB1 (0.52) | CTNNB1WNT3ANPC1RAB9ACCNC | |
| SCHEMBL17350595 | 0.83 | NPC1 (0.48) | NPC1RAB9AHSD11B1SLC18A3SIGMAR1 | |
| SCHEMBL10243905 | 0.83 | NPC1 (0.48) | NPC1RAB9AHSD11B1SLC18A3SIGMAR1 | |
| SCHEMBL10243665 | 0.81 | HSD11B1 (0.42) | CCNCCDK8HSD11B1SLC18A3SIGMAR1 | |
| SCHEMBL17350637 | 0.81 | HSD11B1 (0.42) | CCNCCDK8HSD11B1SLC18A3SIGMAR1 | |
| SCHEMBL17350984 | 0.80 | POLB (0.57) | NPC1RAB9AHSD11B1SLC18A3SIGMAR1 | |
| SCHEMBL10243883 | 0.80 | POLB (0.57) | NPC1RAB9AHSD11B1SLC18A3SIGMAR1 | |
| SCHEMBL10244152 | 0.79 | SLC18A3 (0.43) | NPC1RAB9ACCNCCDK8HSD11B1 | |
| SCHEMBL17350946 | 0.79 | SLC18A3 (0.43) | NPC1RAB9ACCNCCDK8HSD11B1 | |
| SCHEMBL10243769 | 0.79 | ESR1 (0.49) | NPC1RAB9ASLC18A3SIGMAR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | HSD11B1, HSD11B2, HSD17B1 | CTNNB1 761/4885WNT3A 1512/4885NPC1 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.