SCHEMBL10244592

SCHEMBL10244592

CNC(=O)NCCN(CCO)[C@@H](C)c1ccccc1OC

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.41
LPAR1 Q92633 1/20 0.38
MTNR1A P48039 3/20 0.37
MTNR1B P49286 3/20 0.37
HSD17B10 Q99714 1/20 0.36
HTT P42858 2/20 0.36
HPGD P15428 1/20 0.36
ANPEP P15144 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
POLB P06746 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10244546 0.89 L3MBTL1 (0.42) L3MBTL1LPAR1MTNR1AMTNR1BHSD17B10
SCHEMBL10282712 0.85 SLC6A4 (0.43) L3MBTL1MTNR1AMTNR1BHSD17B10HTT
SCHEMBL10244221 0.80 ALDH1A1 (0.38) L3MBTL1HSD17B10HTTMEN1KMT2A
SCHEMBL10243117 0.77 L3MBTL1 (0.41) L3MBTL1MTNR1AMTNR1BHSD17B10HTT
SCHEMBL10282559 0.77 HPGD (0.42) L3MBTL1MTNR1AMTNR1BHSD17B10HTT
SCHEMBL334589 0.76 MC4R (0.38) L3MBTL1HTTMEN1KMT2APOLB
SCHEMBL334590 0.76 MC4R (0.38) L3MBTL1HTTMEN1KMT2APOLB
SCHEMBL10244325 0.74 MTNR1A (0.38) L3MBTL1LPAR1MTNR1AMTNR1BHTT
SCHEMBL10282710 0.72 APP (0.43) L3MBTL1HTTHPGDMEN1KMT2A
SCHEMBL10243705 0.72 HCRTR1 (0.43) L3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8097708-B2 10a-Azalide compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2012-01-17 US disclosed
US-8097708-B2 10a-Azalide compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2012-01-17 US disclosed
US-20090281292-A1 10a-Azalide Compound MEIJI SEIKA PHARMA CO., LTD. (JP) 2009-11-12 US disclosed
US-20090281292-A1 10a-Azalide Compound MEIJI SEIKA PHARMA CO., LTD. (JP) 2009-11-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090281292-A1 10a-Azalide Compound IL17A, AZI2, HDAC9 L3MBTL1 2853/4885LPAR1 775/4885MTNR1A 2892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.