Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10282909 | 0.83 | CCR5 (0.44) | OPRD1OPRK1 | |
| SCHEMBL10246305 | 0.76 | OPRM1 (0.75) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL8485004 | 0.76 | GAA (0.53) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL3951711 | 0.76 | GAA (0.50) | KDM4E | |
| SCHEMBL10246299 | 0.74 | CYP3A4 (0.36) | SLC6A4KCNH2P2RX7 | |
| SCHEMBL10246456 | 0.73 | HSD11B1 (0.42) | SLC6A4KCNH2P2RX7 | |
| SCHEMBL8485288 | 0.73 | GAA (0.51) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL3951730 | 0.73 | GAA (0.48) | KDM4E | |
| SCHEMBL16565569 | 0.73 | OPRM1 (0.64) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL10246273 | 0.72 | OPRM1 (0.45) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124624-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-20090264407-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264407-A1 | Substituted Sulfonamide Compounds | CNR1, SUCNR1, OPRL1 | OPRM1 20/4885SLC22A1 840/4885SLC6A4 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.