Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ4 | P56696 | 3/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2515901 | 0.89 | EGLN2 (0.35) | KCNQ4KCNQ5PTGDR2BRD9CYP17A1 | |
| SCHEMBL1027082 | 0.87 | PKM (0.37) | — | |
| SCHEMBL1027080 | 0.87 | PKM (0.37) | — | |
| SCHEMBL1026146 | 0.86 | PTGES (0.38) | KCNQ4KCNQ5PTGDR2BRD9KDR | |
| SCHEMBL13622747 | 0.85 | NAMPT (0.39) | PTGDR2BRD9CYP17A1KDRMAP4K4 | |
| SCHEMBL1025849 | 0.84 | BRD9 (0.36) | PTGDR2BRD9CYP17A1KDRPTPN11 | |
| SCHEMBL4348212 | 0.82 | CYP17A1 (0.33) | KCNQ4KCNQ5BRD9CYP17A1FGFR1 | |
| SCHEMBL1025177 | 0.78 | KCNQ4 (0.36) | KCNQ4KCNQ5BRD9CYP17A1ATR | |
| SCHEMBL1024630 | 0.77 | FFAR1 (0.43) | PTGDR2KDRGRM5PTGES | |
| SCHEMBL1023856 | 0.75 | PKM (0.40) | KCNQ4KCNQ5PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |