Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027080 | 1.00 | PKM (0.37) | PKMHTTMMP1MMP2MMP9 | |
| SCHEMBL1023858 | 0.88 | PKM (0.40) | PKMHTTMMP1MMP2MMP9 | |
| SCHEMBL1023856 | 0.88 | PKM (0.40) | PKMHTTMMP1MMP2MMP9 | |
| SCHEMBL1024644 | 0.87 | KCNQ4 (0.35) | — | |
| SCHEMBL2515901 | 0.85 | EGLN2 (0.35) | — | |
| SCHEMBL13622742 | 0.85 | PKM (0.41) | PKMHTTMMP1MMP2MMP9 | |
| SCHEMBL1022924 | 0.84 | GAA (0.40) | PKMHTTMMP1MMP2MMP9 | |
| SCHEMBL1022925 | 0.84 | GAA (0.40) | PKMHTTMMP1MMP2MMP9 | |
| SCHEMBL13622511 | 0.76 | MMP1 (0.45) | PKMHTTMMP1MMP2MMP9 | |
| SCHEMBL1025541 | 0.76 | MAPT (0.42) | PKMHTTMMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |