Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023575 | 0.93 | L3MBTL1 (0.39) | L3MBTL1BACE1POLBATMNPC1 | |
| SCHEMBL1023884 | 0.87 | CYP1A2 (0.38) | BACE1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL1025606 | 0.86 | GRM5 (0.38) | SRCBRAFKDRKDM5AKDM4C | |
| SCHEMBL1023290 | 0.84 | NR1H2 (0.36) | PTGS2 | |
| SCHEMBL1026639 | 0.80 | PDE10A (0.37) | LMNANPC1RAB9AKDM1ACYP1A2 | |
| SCHEMBL1027586 | 0.79 | GRM8 (0.36) | BACE1LMNAKDM1APTGS2CYP1A2 | |
| SCHEMBL1023890 | 0.79 | MEN1 (0.36) | PTGS2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3581885 | 0.77 | NPC1 (0.44) | POLBNPC1RAB9APTGS2TSHR | |
| SCHEMBL1026094 | 0.77 | PDE10A (0.39) | PTGS1PTGS2 | |
| SCHEMBL1025108 | 0.77 | PDE10A (0.37) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274285-A1 | NOVEL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2011-01-19 | — | — | EP | claimed |
| WO-2009127612-A1 | NOVEL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | claimed |
| EP-2274285-A1 | NOVEL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127612-A1 | NOVEL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | disclosed |