Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026639 | 0.89 | PDE10A (0.37) | GRM8CYP1A2GRM7PDE10AMAOB | |
| SCHEMBL1025108 | 0.86 | PDE10A (0.37) | PDE10APDE2APTGS2TP53IGF1R | |
| SCHEMBL1023575 | 0.85 | L3MBTL1 (0.39) | GRM8CYP1A2GRM7PDE10ABACE1 | |
| SCHEMBL1025104 | 0.84 | PDE10A (0.36) | PDE10AMAOBLMNA | |
| SCHEMBL1023884 | 0.84 | CYP1A2 (0.38) | GRM8CYP1A2GRM7PDE10APDE2A | |
| SCHEMBL1024672 | 0.79 | L3MBTL1 (0.39) | CYP1A2BACE1PTGS2LMNAKDM1A | |
| SCHEMBL1026094 | 0.77 | PDE10A (0.39) | PDE10APDE2APTGS2TP53IGF1R | |
| SCHEMBL1023890 | 0.77 | MEN1 (0.36) | PDE10APTGS2 | |
| SCHEMBL19953206 | 0.75 | POLB (0.38) | CYP1A2PDE10ABACE1PTGS2 | |
| SCHEMBL1025996 | 0.73 | PDE10A (0.35) | PDE10APDE2ATP53IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274285-A1 | NOVEL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2011-01-19 | — | — | EP | claimed |
| WO-2009127612-A1 | NOVEL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | claimed |
| EP-2274285-A1 | NOVEL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127612-A1 | NOVEL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | disclosed |