Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023884 | 0.93 | CYP1A2 (0.38) | BACE1PDE10APTGS1PTGS2CYP1A2 | |
| SCHEMBL1024672 | 0.93 | L3MBTL1 (0.39) | L3MBTL1BACE1POLBATMNPC1 | |
| SCHEMBL1026639 | 0.86 | PDE10A (0.37) | PDE10ANPC1RAB9AIGF1RKDM1A | |
| SCHEMBL1027586 | 0.85 | GRM8 (0.36) | BACE1PDE10AIGF1RKDM1APTGS2 | |
| SCHEMBL1025104 | 0.81 | PDE10A (0.36) | PDE10A | |
| SCHEMBL19953206 | 0.81 | POLB (0.38) | L3MBTL1BACE1PDE10APOLBPTGS1 | |
| SCHEMBL1025606 | 0.79 | GRM5 (0.38) | KDM5AKDM4CKDM5B | |
| SCHEMBL1023290 | 0.77 | NR1H2 (0.36) | PDE10APTGS2 | |
| SCHEMBL12856308 | 0.75 | GRM5 (0.46) | L3MBTL1BACE1POLBATMNPC1 | |
| SCHEMBL19967295 | 0.74 | KMT2A (0.34) | L3MBTL1NPC1RAB9ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274285-A1 | NOVEL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2011-01-19 | — | — | EP | claimed |
| WO-2009127612-A1 | NOVEL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | claimed |
| EP-2274285-A1 | NOVEL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127612-A1 | NOVEL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | disclosed |