Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22304838 | 0.83 | PYCR1 (0.60) | PYCR1NPC1CXCR3MEN1RAB9A | |
| SCHEMBL19300926 | 0.79 | PTGS1 (0.46) | PTGS1RXRARXRBRXRG | |
| SCHEMBL15164028 | 0.77 | RXRA (0.44) | PYCR1MCHR1PTGS1KCNH2HTR2C | |
| SCHEMBL3191532 | 0.77 | PYCR1 (0.67) | PYCR1NPC1HRH3CXCR3MEN1 | |
| SCHEMBL30093198 | 0.77 | PYCR1 (0.67) | PYCR1NPC1HRH3CXCR3MEN1 | |
| SCHEMBL185132 | 0.74 | LMNA (0.49) | MCHR1PTGS1RXRARXRBRXRG | |
| SCHEMBL4412749 | 0.73 | PTGS1 (0.60) | PYCR1PTGS1MEN1KMT2A | |
| SCHEMBL27825225 | 0.72 | HRH3 (0.77) | PYCR1MCHR1HRH3ALOX5RIPK1 | |
| SCHEMBL3582959 | 0.71 | PTGS1 (0.40) | PTGS1RXRARXRBRXRGMEN1 | |
| SCHEMBL3591800 | 0.71 | AGXT (0.41) | PTGS1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297103-B1 | HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-01-04 | — | — | EP | disclosed |