Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 12/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10247666 | 0.80 | SMN1; SMN2 (0.57) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL10250868 | 0.76 | NPC1 (0.49) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL10247601 | 0.76 | HDAC1 (0.45) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL10247665 | 0.76 | MAPT (0.53) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL4507350 | 0.74 | SMN1; SMN2 (0.64) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL29915496 | 0.73 | NOTUM (0.51) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL28574227 | 0.73 | KDM4E (0.61) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL12227999 | 0.73 | DPP4 (0.57) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL5884907 | 0.73 | RAB9A (0.41) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL10250866 | 0.72 | RAB9A (0.47) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | HPGD 1718/4885ALDH1A1 2610/4885KDM4E 3490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.