Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10248707 | 0.86 | TSHR (0.35) | TSHRBRD4HCAR2KEAP1NFE2L2 | |
| SCHEMBL10248604 | 0.81 | HCAR2 (0.34) | TSHRBRD4HCAR2KEAP1NFE2L2 | |
| SCHEMBL10248622 | 0.79 | TSHR (0.31) | TSHR | |
| SCHEMBL22691368 | 0.76 | TSHR (0.33) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL10248636 | 0.75 | ALDH1A1 (0.40) | ALDH1A1POLBMAPTTDP1TSHR | |
| SCHEMBL11225493 | 0.75 | HCAR2 (0.39) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL23533359 | 0.75 | PRKCA (0.40) | ALDH1A1POLBTSHR | |
| SCHEMBL14599741 | 0.73 | HCAR2 (0.37) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL1709394 | 0.72 | ALDH1A1 (0.38) | ALDH1A1POLBMAPTTDP1ITGB1 | |
| SCHEMBL5084459 | 0.71 | PRKCA (0.34) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127451-A1 | SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2018-05-10 | — | — | US | disclosed |
| US-9688714-B2 | Substituted purine compounds | Epizyme, Inc. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160368943-A1 | SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-20150366893-A1 | SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-24 | — | — | US | disclosed |
| US-9096634-B2 | Substituted purine and 7-deazapurine compounds | Epizyme, Inc. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140051654-A1 | Substituted Purine and 7-Deazapurine Compounds | Epizyme, Inc. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8580762-B2 | Substituted purine and 7-deazapurine compounds | Epizyme, Inc. (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120142625-A1 | Substituted Purine And 7-Deazapurine Compounds | Epizyme, Inc. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150366893-A1 | SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | TPMT, DIMT1, DAZAP1 | ALDH1A1 592/4885POLB 1016/4885MAPT 1522/4885 |
| US-20140051654-A1 | Substituted Purine and 7-Deazapurine Compounds | TPMT, DIMT1, DAZAP1 | ALDH1A1 592/4885POLB 1016/4885MAPT 1522/4885 |
| US-20160368943-A1 | SUBSTITUTED PURINE COMPOUNDS | DIMT1, DOT1L, TPMT | ALDH1A1 922/4885POLB 1172/4885MAPT 2709/4885 |
| US-20180127451-A1 | SUBSTITUTED PURINE COMPOUNDS | DIMT1, DOT1L, TPMT | ALDH1A1 922/4885POLB 1172/4885MAPT 2709/4885 |
| US-20120142625-A1 | Substituted Purine And 7-Deazapurine Compounds | TPMT, DIMT1, DAZAP1 | ALDH1A1 592/4885POLB 1016/4885MAPT 1522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.