Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27832409 | 0.85 | HTT (0.57) | LTA4HEPHX2LMNASMN1; SMN2HTT | |
| SCHEMBL184171 | 0.82 | LTA4H (0.51) | LTA4HEPHX2LMNASMN1; SMN2HTT | |
| SCHEMBL184800 | 0.80 | LTA4H (0.50) | LTA4HEPHX2LMNASMN1; SMN2HTT | |
| SCHEMBL8808661 | 0.79 | HTT (0.61) | LTA4HEPHX2LMNASMN1; SMN2HTT | |
| SCHEMBL2734654 | 0.78 | NPC1 (0.46) | LTA4HEPHX2LMNASMN1; SMN2HTT | |
| SCHEMBL18415593 | 0.78 | ALDH1A1 (0.65) | LMNASMN1; SMN2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL15164010 | 0.77 | LTA4H (0.47) | LTA4HEPHX2LMNASMN1; SMN2HTT | |
| SCHEMBL8497924 | 0.77 | LTA4H (0.79) | LTA4HEPHX2LMNASMN1; SMN2HTT | |
| SCHEMBL13568182 | 0.76 | LMNA (0.53) | LMNAHTTALDH1A1KDM4ECYP3A4 | |
| SCHEMBL184395 | 0.74 | GRM2 (0.46) | LTA4HEPHX2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297103-B1 | HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-01-04 | — | — | EP | disclosed |