Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 4/20 | 0.71 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 8/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | CRHBP | P24387 | 1/20 | 0.63 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906561 | 0.89 | KAT2B (0.74) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL16151564 | 0.88 | KAT2B (0.72) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL3636228 | 0.87 | KAT2B (0.69) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL6250970 | 0.87 | KAT2B (0.66) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL24076 | 0.86 | KAT2B (0.69) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL29377506 | 0.86 | KAT2B (0.69) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL16378801 | 0.86 | KAT2B (0.69) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL14063303 | 0.84 | HCAR3 (0.65) | KAT2BHCAR3MAPTALDH1A1RAB9A | |
| SCHEMBL9725410 | 0.83 | ALDH1A1 (0.72) | KAT2BHCAR3MAPTALDH1A1CYP3A4 | |
| SCHEMBL4858189 | 0.83 | KAT2B (0.74) | KAT2BHCAR3MAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461181-B2 | Fused heterocyclic compound and use thereof | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 2013-06-11 | — | — | US | disclosed |
| US-8273764-B2 | Fused heterocyclic compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-09-25 | — | — | US | disclosed |
| US-20120178779-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED | 2012-07-12 | — | — | US | disclosed |
| US-20120015975-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178779-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | C3AR1, C9, C5 | KAT2B 1631/4885HCAR3 107/4885MAPT 4423/4885 |
| US-20120015975-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | C3AR1, C9, C5 | KAT2B 1631/4885HCAR3 107/4885MAPT 4423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.