Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1024957 | 1.00 | MEN1 (0.49) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1028344 | 0.84 | F2 (0.40) | MAPTSMN1; SMN2HTT | |
| SCHEMBL1026635 | 0.81 | CHRNB2 (0.48) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1026632 | 0.81 | CHRNB2 (0.48) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1026407 | 0.81 | MEN1 (0.60) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1026409 | 0.81 | MEN1 (0.60) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1026801 | 0.81 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL1026803 | 0.81 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL13623175 | 0.80 | MEN1 (0.51) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL2453168 | 0.78 | TP53 (0.49) | MEN1KMT2AALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |