Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1024960 | 0.84 | MEN1 (0.49) | MAPTHTTSMN1; SMN2 | |
| SCHEMBL1024957 | 0.84 | MEN1 (0.49) | MAPTHTTSMN1; SMN2 | |
| SCHEMBL1028340 | 0.80 | CTSC (0.42) | MAP3K5 | |
| SCHEMBL1025784 | 0.80 | TSHR (0.40) | MAPTTSHRMAOBTP53CYP3A4 | |
| SCHEMBL1075413 | 0.79 | F2 (0.44) | F2MAPTTSHRMAOB | |
| SCHEMBL13623174 | 0.78 | ITK (0.47) | MAPTTSHRPDK2SMN1; SMN2 | |
| SCHEMBL1026693 | 0.76 | ALDH1A1 (0.42) | CYP3A4NPC1SMN1; SMN2 | |
| SCHEMBL1024327 | 0.74 | PTGS1 (0.53) | HTTRAB9ASMN1; SMN2 | |
| SCHEMBL1028225 | 0.73 | ALDH1A1 (0.48) | MAPTHTTSMN1; SMN2 | |
| SCHEMBL1025733 | 0.72 | ALDH1A1 (0.59) | MAPTNPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |