Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 17/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10199323 | 0.94 | XIAP (0.44) | XIAPCASP1CYP3A4 | |
| SCHEMBL10200343 | 0.93 | XIAP (0.43) | XIAPCASP1CYP3A4 | |
| SCHEMBL10249823 | 0.92 | CASP1 (0.47) | XIAPCASP1CYP3A4 | |
| SCHEMBL10201847 | 0.88 | CASP1 (0.43) | XIAPCASP1CYP3A4 | |
| SCHEMBL10249838 | 0.87 | XIAP (0.46) | XIAPCYP3A4 | |
| SCHEMBL644702 | 0.87 | CASP1 (0.47) | XIAPCASP1CYP3A4 | |
| SCHEMBL644704 | 0.87 | CASP1 (0.47) | XIAPCASP1CYP3A4 | |
| SCHEMBL10249692 | 0.86 | CASP1 (0.46) | XIAPCASP1CYP3A4 | |
| SCHEMBL10249782 | 0.86 | XIAP (0.51) | XIAPCASP1CYP3A4 | |
| SCHEMBL10249714 | 0.86 | XIAP (0.42) | XIAPCASP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119631-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110178069-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178069-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | IL1A, IFNAR1, IL1B | XIAP 257/4885CASP1 6/4885CYP3A4 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.