SCHEMBL10258277

SCHEMBL10258277

Cc1cccc(C)c1C1=C(O)[C@H]2[C@@H](C1=O)[C@@H]1CC[C@H]2O1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.44
BCHE P06276 3/20 0.37
OPRD1 P41143 2/20 0.37
TBXA2R P21731 1/20 0.35
LMNA P02545 2/20 0.35
ALDH1A1 P00352 1/20 0.35
KDM4E B2RXH2 1/20 0.33
GMNN O75496 1/20 0.33
PPM1B O75688 1/20 0.33
PPP1CC P36873 1/20 0.33
TFPI2 P48307 1/20 0.33
RAB9A P51151 1/20 0.33
PPP5C P53041 1/20 0.33
PPP1CA P62136 1/20 0.33
PMP22 Q01453 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
TP53 P04637 1/20 0.33
CYP2D6 P10635 1/20 0.33
NFKB1 P19838 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6727345 0.84 L3MBTL1 (0.39) L3MBTL1LMNAALDH1A1TFPI2MAOA
SCHEMBL10187541 0.83 L3MBTL1 (0.34) L3MBTL1LMNAKDM4EGMNNPPM1B
SCHEMBL13261980 0.83 L3MBTL1 (0.34) L3MBTL1LMNAKDM4EGMNNPPM1B
SCHEMBL10257698 0.81 KDM4E (0.33) L3MBTL1LMNAALDH1A1KDM4EPPP1CA
SCHEMBL10187603 0.78 TTK (0.34) L3MBTL1
SCHEMBL10187597 0.77 L3MBTL1 (0.34) L3MBTL1ALDH1A1KDM4E
SCHEMBL10187606 0.77 L3MBTL1 (0.31) L3MBTL1MAOAMAOB
SCHEMBL10187612 0.77 MMP13 (0.33) L3MBTL1
SCHEMBL10266766 0.76 LMNA (0.36) L3MBTL1LMNAALDH1A1KDM4EGMNN
SCHEMBL13953329 0.76 LMNA (0.33) L3MBTL1LMNAALDH1A1KDM4EGMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2185564-B1 Herbicidally active cyclopentanedione compounds and derivatives thereof SYNGENTA LTD (GB) 2014-06-18 EP disclosed
US-8754242-B2 Herbicides SYNGENTA CROP PROTECTION LLC (US) 2014-06-17 US disclosed
US-8754242-B2 Herbicides SYNGENTA CROP PROTECTION LLC (US) 2014-06-17 US disclosed
US-20120094832-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2012-04-19 US disclosed
US-20120094832-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2012-04-19 US disclosed
WO-2009019005-A2 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2009-02-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120094832-A1 NOVEL HERBICIDES DDT, CYP1B1, CYP1A1 L3MBTL1 1525/4885BCHE 121/4885OPRD1 1570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.