Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 9/20 | 0.38 |
| ▸ | ITK | Q08881 | 6/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023949 | 0.92 | ALDH1A1 (0.40) | ALDH1A1EGFRBTKKDM4EGAA | |
| SCHEMBL1026292 | 0.87 | SYK (0.42) | ALDH1A1SYKEGFRITKBTK | |
| SCHEMBL1026319 | 0.86 | SYK (0.42) | ALDH1A1SYKEGFRITKBTK | |
| SCHEMBL1025701 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SYKEGFRITKBTK | |
| SCHEMBL13623035 | 0.82 | SYK (0.55) | ALDH1A1SYKEGFRITKCCNT1 | |
| SCHEMBL13623036 | 0.79 | SYK (0.48) | ALDH1A1SYKEGFRITKBTK | |
| SCHEMBL4328037 | 0.79 | NR3C2 (0.47) | ALDH1A1SYKEGFRITKBTK | |
| SCHEMBL1025143 | 0.78 | BCL6 (0.40) | ALDH1A1SYKEGFRITKBTK | |
| SCHEMBL1027536 | 0.78 | SYK (0.44) | SYKEGFRITKBTKCCNT1 | |
| Hydrochloric Acid SCHEMBL1026587 | 0.78 | SYK (0.47) | ALDH1A1SYKEGFRITKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |